The change of intraocular pressure and bleb morphology by using mitomycin c drugug delivery system during filtrable operation of rabbit eyes

Objective To investigate the efficacy of mitomycin C drug delivery system(MMC DDS ) as a new glaucoma anti-scarring agent by observingthe change of intraocular pressure and bleb morphology. Methods ①The material of drug delivery system is a polymer polylactioglycolic acid (PLGA).0.02mg mitomgcin C was incorporated into PLGA.It will dissolve within 28 days. ②Filtering surgery was performed in both eyes of 24 white rabbits.The all right eyes received MMC DDS,12 left eyes only operation.Results MMC DDS was associated with successful filtration surgery, evidenced by bleb morphology compared with control group, the IOP remained consistently lower than baseline measurements in the MMC DDS group. Conclusion MMC DDS has strong effects on reduction inflammatory cells activity and fibroblast activity in surgery sites. MMC DDS was found to improve glaucoma filtration Surgery outcome. It has potential as a new safe and effective anti-scarring agent for easy use in glaucoma filtration surgery.