Expressions of Matrix Metalloproteinase-9,Tissue Inhibitor of Matrix Metalloproteinase-1 and Their mRNA in Meningiomas

Objective To study the relationship of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of matrix metallopro-teinase-1(TIMP-1) and their mRNA expressions with invasveness of meningiomas.Methods The expressions of MMP-9 and TIMP-1 were determined by immuhistochemical SP method in 70 cases of meningoimas,which included 40 cases of benign meningoimas,15 of atypical meningoimas and 15 of anaplastic meningiomas.The expression of MMP-9 mRNA and TIMP-1 mRNA were detected by hybridization in situs and absorbance were measured in 70 all the meningoimas.Results The postive rates of MMP-9 and TIMP-1 expressions in benign meningiomas ones were 35.00%,and 52.50% respectively and the positive rate in the malignant meningioma including atypical and anaplastic ones were 76.67% and 53.33% respectively.There was significant difference in the positive rate of MMP-9,not TIMP-1,expression between the benign meningiomas and malignant meningiomas(P0.05).There was significant difference in expressions of MMP-9 mRNA and TIMP-1 mRNA between benign meningiomas and malignant meningiomas(P0.05).Conclusions MMP-9 is related to the biological speciality of meningiomas and can accelerate the invasive growth of the meningiomas.The imbalance of MMP-9 and TIMP-1 expressions is related to the degree of malignancy and invasiveness of meningiomas.MMP-9 mRNA and TIMP-1 mRNA take part in the development of meningiomas and may be related of biological behavior of meningiomas.