The expression of hASIP in human breast carcinoma and its relation to clinico-pathological data

Objective To detect the expression of human atypical protein kinase C (PKC)-isotype-specific-interacting-protein(hASIP) in human breast carcinoma(BC) and analyze its relation to clinico-pathological data. The function of hASIP in BC pathogenesis is discussed. Methods By RT-PCR,the expression of hASIP in BC tissues and surrounding non-tumorous mammary tissues was studied. Results hASIP-a was detected in 92.5%(49/53) of BC tissues and 75.5%(40/53) of surrounding non-tumorous tissues (P0.05); and hASIP-b in 54.7%(29/53) of BC tissues and 43.4%(23/53) of surrounding non-tumorous tissues (P0.05). Compared with the surrounding non-tumorous tissues,the expression of hASIP-a was upregulated in 64.2%(34/53) of BC tissues. Nevertheless,the expression of hASIP-b was upregulated only in 32.1%(17/53) of BC tissues (P0.01). The overexpression of hASIP-a was correlated with age50 years,early stage of TNM,estrogen recept(ER) positive and invasive carcinomas(excluding invasive ductal carcinoma) in BC patients(P0.05). Conclusions hASIP-a is overexpressed in human breast carcinoma. The overexpression of hASIP-a is correlated with age50 years,early stage of TNM,ER positive and invasive carcinomas(excluding invasive ductal carcinoma) in BC patients.