Expression of MGMT and Survivin in Breast Cancer and Its Clinical Significance

Objective:To investigate the expression of MGMT and Survivin in breast cancer and its clinical significance.Methods :Speci mens from breast adenoma and breast cancer were taken and had been Formalin-fixed,paraffin-embedded.With Strept Avidin-Biotin Complex(SABC) immunohistochemical technique,the expression of MGMT and Survivinin these specimens was examined.Results :It was found that there were significant differences between MGMT and Survivin in breast adenoma and breast cancer.The expression of MGMT was correlated with the patients age and lymph node metastasis,while the expression of Survivin was associated with lymph node metastasis only.Meanwhile,the expression of MGMT was correlated with that of Survivin(r=0.34,P0.01).Conclusion :It was concluded that the abnormal expressions of MGMT and Survivin were associated with lymph node metastasis.They possibly could be useful indexes for the primary screening and the prognosis of breast cancer.The examination of them may have an important guiding significance in the chemotherapy strategy.