Nano-HA/PRP Used in Repairing Cleft of Alveolus:an Animal Study.

Objective:To study the biological property of nano-HA/PRP used in repairing cleft of alveolus and the function of PRP during the course of bone repair.Methods: 40 male Japanese rabbits were randomly divided into two groups evenly: nano-HA/PRP and nano-HA.Clefts of alveolus were made by operation on each side of mandible,and two months later they were repaired with two materials.The animals were sacrificed at 2,4,8,12 and 24 weeks postoperative.Samples were observed by histological and histomorphometric evaluation.Results: On the time of 2 weeks after operation,the bone forming were more active in nano-HA/PRP group than that in the control group.12 weeks after operation,the materials in two groups were all Absorbed completely.24 weeks after operation,the proportion of average lost height of new forming bone was 11.9% in nano-HA/PRP group and 12.4% in the control group.Conclusion: Nano-HA was a good material for the repairing of cleft of alveolus,and PRP promote bone healing in the early stage of bone repair.