Analysis of 6 kind of infection modes of serum HBV and liver fuction in 550 subjects

Objective To investigate the infection statue of new drug experimenters with hepatitis B, as well as liver fuction in 6 kind of infection modes of serum HBV, and to provide evidence for clinical therapy of hepatitis B.Methods 5 immunological HBV markers were measured with ELISA in serum sample of 550 patients before new drug test. Velocity method was applied to detecting serum TBiL, ALT, AST, γ-GT and GLO.Results New drug experimenters with hepatitis B mainly suffered from small three positive [HBsAg (+), anti-HBe (+) and anti-HBc (+)] (52.9%), followed by big three positive [HBsAg (+), HBeAg (+) and anti-HBc (+)] (28.2%). The rate of hepatic function abnormality was significantly higher in small three positive group than that of the other groups (P0.01), while the rate of hepatic function abnormality was much higher in big three positive group than that of the other groups except big three positive group (P0.05).Conclusion In 550 cases of new drug experimenters, HBV are all positive, mostly in small three positive or big three positive mode. The rate of hepatic function abnormality is markedly elevated in 6 kind of infected modes, in which big three positive mode is the highest, followed by 1, 3 mode andsmall three positive mode.