Influence of NPZBD on EGF Positive neurons in aged hypomnesia rat's brain

Objective To discuss the influence of NPZBD on ability of learning and memory and bFGF positive neurons in Caudate putamen and cortex of aged hypomnesia rats.Methods The aged rats were randomly divided into normal memory group,hypomnesia group,NPZBD low dose treatment group and NPZBD large dose treatment group.The aged rats of treatment group were administered with NPZBD 0.05 g/(kg·d) and 0.1 g/(kg·d)for 15 d.All rats were tested ability of learning and memory with Morris water maze after the administration and detected the changes of bFGF Positive neurons in Caudate putamen and cortex with immunohistochemistry.Results In 4th to 5th day of splace navigation,the escape latency of rats in NPZBD large dose treatment group was significantly shorter than that of hypomnesia group,there was significant difference(P0.05);in space probe test,the time in second quadrant,time of first through platform,times of through platform of rats in NPZBD large dose treatment group was significantly different with the rats in hypomnesia group(P0.05).The bFGF positive neurons in Caudate putamen and cortex of aged hypomnesia rats in NPZBD large dose treatment group was significantly increased than those of hypomnesia group(P0.05).Conclusion NPZBD has obvious promotion effect on ability of learning and memory in aged hypomnesia rats.The mechanism might be connected with increased bFGF positive neurons in Caudate putamen and cortex of aged hypomnesia rats.