Inhibition of curcumin on the proliferation in HeLa cell lines through Notch signaling pathway
Maternal and Child Health Care of China(2008)
摘要
Objective:To investigate the regulatory effect of curcumin on the proliferation of human cervical carcinoma cell line HeLa in vitro and its mechanisms.Methods:The antiproliferative effects of curcumin against HeLa cell lines was determined by the MTT dye uptake method.The expression of Notch1,Notch2,Jagged1,Bcl-2,Bax mRNA were evaluated by reverse transcriptase-polymerase chain reaction(RT-PCR)analysis.Results:Curcumin inhibited the growth of HeLa cells on a time-and dose-depending manner.Curcumin downregulated the constitutive expression of Notch1,Notch2,Jagged1,Bcl-2 genes,but upregulated the expression of Bax and the ratio of Bcl-2/Bax decreased,there was no significance in the expression of Jagged1 mRNA.Conclusion:Curcumin can inhibited the proliferation of HeLa cell lines through regulating expression of apoptotic protein related with Notch signaling pathway.
更多查看译文
关键词
curcumin,hela cell lines,notch,pathway
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要