A Scalable Synthesis of MN-447, an Antagonist for Integrins αvβ3 and αIIbβ3

Minoru Ishikawa,Masaki Tsushima,Dai Kubota,Yumiko Yanagisawa,Yukiko Hiraiwa,Yasuo Kojima,Keiichi Ajito,Naomichi Anzai

Organic Process Research & Development（2008）

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摘要

(2S)-Benzenesulfonylamino-3-[3-methoxy-4-{4-(1,4,5,6-tetrahydropyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionic acid, MN-447, is a potent antagonist of the integrins αvβ3 and αIIbβ3. Herei...

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