Analysis of associations between genetic markers of erythrocytes of ав0, Rh, mn, P, kell blood group systems and arterial hypertension at the Altai Republic population

Objectives: the aim is to estimate the share of people with AH among the Tubalars and nonindigenous inhabitants of the Altai Republic taking into account a sex, an ethnic origin and to analyze genetic predisposition to the diseases of АВ0, Rh, MN, P, Kell blood group systems. Materials and methods. There was clinico-epidemiologic survey of the Altai Republic population (sample of 935 people, 663 people of them are Tubalars, 272 people are nonindigenous) aged from 18 till 88 years. Arterial hypertension was diagnosed according to criteria of WHO/MOAG of 1999. The study of genetic markers was carried out according to the standard methodology, blood group systems were defined: ABO, «full» Rhesus factor, MN, P, Kell. The sample size of different systems made from 301 to 425 people. The force of association between studied markers and the disease was judged according to the criterion of relative risk. Results. 38,6% Tubalars and 40,8% nonindigenous population were diagnosed with arterial hypertension. The share of people with Rh(+) blood group is larger among Tubalars (94,6%) in comparison with nonindigenous representatives (87,4%; p<0,05). The full Rhesus factor CCDee and CcDEe phenotypes were registered more often among Tubalars, and the ccDee, CcDee, ccDEe, Ccddee phenotypes – among nonindigenous ethnic group. The MM phenotype was brought out more often among people of indigenous nationality (64,5% against 43,7%), whereas the MN and NN phenotypes – among people of nonindigenous nationality (40,4% against 28,5% and 15,9% against 7,0%; p<0,05). There were established the risk of development of AH for people with Rh(-) blood group among Tubalars, positive associative connection with AH disease for the people having the MN phenotype and resistance of people with Rh(+) blood group and the NN phenotype. Conclusion. The share of people with AH in the Altai Republic do not differ from the average rates in Russia (37,9% among men, 40,0% among women). There were brought out ethnic differences in blood group distribution of Rhesus and MN systems.