Research on the Gene Changes of Rat Cardiovascular Central Tissue under Simulated Weightlessness

Objective To study the molecular mechanism of cardiovascular regulatory functional changes in rats under simulated weightlessness condition. Methods The gene changes of cardiovascular central tissue in five control rats and the five models were examined with gene chip technology to display the essence of cardiovascular functional changes. Results The gene chips showed that ADP-ribosylation factor-like2,progestin and adipoQ receptor family member IV,pyruvate dehydrogenasekinase,isozyme1;somatostatin,sst, transmembraneprotease, tmprss5 and serine5(spinesin)were changed in the cardiovascular center under simulated weightlessness. Conclusion Under weightlessness the changes of cardiovascular function are related to the signal channels about Arl2, Paqr4, Pdk1, Sst and Tmprss.