The application of BNP in the evaluation of severity and prognosis of coronary artery disease

Objective To investigate the application and role of B-type natriuretic peptide(BNP) determination in the evaluation of severity and prognosis of coronary artery disease.Methods According to the result of angiograph,350 patients suffering the chest pain were classified into non-coronary artery disease group(95 patients) and coronary artery disease group(256 patients)[stable angina(SA) group(111 patients) and acute coronary syndrome(ACS) group(145 patients)].The general information,the number of pathological change branches and the Gensini score of patients were recorded.The level of BNP was detected by chemiluminescence immunoassay.The major adverse cardiac events(MACE) were recorded in 1 year follow-up period.The differences of the level of BNP with the number of pathological change branches and the MACE in different groups were analyzed.Results The coronary artery disease group had the higher level of BNP [(137.95±21.58) pg/mL] than that of non-coronary artery disease group [(89.05±9.18) pg/mL,P0.01].The level of BNP in the ACS patients [(177.83±22.16) pg/mL] was dramatically higher than that in SA patients [(121.17±19.98) pg/mL,P0.01].The level of BNP in the patients with three stenosis branches was higher than that of two stenosis branches,and the level of BNP was higher in two stenosis branches than in single one branch(P0.05).According to the BNP level,the Gensini scores were classified into low group(29.10±4.54),middle group(37.76±6.91) and high group(58.46±3.71) with statistical significance(P0.05),which their BNP levels were 112.05±9.52,147.56±17.12 and(180.03±22.57)pg/mL in the low,middle and high groups respectively.There were 29 MACE during the follow-up period,including 3 cases with non-cardiac disease,12 cases with acute and selective angiograph,9 cases administrated the second percutaneous coronary intervention(PCI) and 5 cardiac death cases.The patients suffered from the MACE had higher level of BNP [(205.12±14.73)pg/mL] than the patients without MACE [(108.27±11.96) pg/mL,P0.01].Conclusions BNP is one useful marker for the evaluation of severity and prognosis of coronary artery disease.