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Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

Richard M. Keenan,William H. Miller,M. Amparo Lago,Fadia E. Ali,Bondinell William E,James F. Callahan,Raul R. Calvo,Russell D. Cousins, S M Hwang,Dalia R. Jakas,Thomas W. Ku,Chet Kwon,Thomas T. Nguyen,Valerie A. Reader,David J. Rieman,Steven T. Ross,Dennis T. Takata,Irene N. Uzinskas,Catherine C.K. Yuan,Brian R. Smith

ChemInform（1998）

Cited 13|Views5
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Abstract
In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (αvβ3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both activity and pharmacokinetics.
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benzimidazole derivatives,arginine mimetics,receptor
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