Change of Serum Platelet Activating Factors in Newborns With Pulmonary Hemorrhage

Objective To observe the level change of the serum platelet activating factors(PAF) and the relationship with prognosis in newborns with pulmonary hemorrhage.Methods According to prognosis and the outcome,the newborns with pulmonary hemorrhage were divided to three stages;early stage(n =28),acute stage(n =28),survival stage (n = 20) or death stage(n = 8 ).20 healthy neonates served as control group.Enzyme-linked immunosorbent assay (ELISA) were used to measure the levels of serum PAF in groups.Results The levels of serum PAF in newborns with pulmonary hemorrhage in early stage and acute stage were significantly higher than those in controls(P 0.01).The level of serum PAF in death stage was higher than that in acute stage group(P 0.05).The level of serum PAF in survival stage was markedly lower than that in acute stage group(P 0.01 ),but it was still higher than that in control group(P 0. 01).Conclusion PAF may be involved in the process of lung injury in pulmonary hemorrhage of the newborn.Dynamic monitoring of serum PAF is useful for the early prevention,treatment and evaluation of diagnosis of pulmonary hemorrhage of the newborn.