Perioperative celecoxib administration in pain management of limbs fracture surgery

Objective To evaluate the effects of perioperative celecoxib administration in pain management of patients undergoing limbs fracture surgery.Methods 290 cases with limbs fracture surgery were divided into three groups,100 cases in A group, oral administration with celecoxib 400mg 8h before surgery,200mg in the same day after surgery and 200mg twice a day during five days after surgery.and 90 cases in B group.Cases,oral administration with celecoxib 200mg in the same day after surgery and 200mg twice a day during five days after surgery.Cases in C group,administration without celecoxib.All the three groups did not restrict the requirements of intravenous analgesic pump,injected opioids after surgery.After surgery,pain intensity was measured with visual analog scale(VAS),and opium analgesic requirements, and the circumstances of vomit were observed.Results In the same day、the first day and second day after surgery,the VAS pain scores of A group were lower than those of other groups significantly(P0.05).However,in the third day,the fourth day,and the fifth day after surgery,there were no significant differences between the three groups in the VAS pain scores(P0.05).From the same day to the fifth day after surgery,the frequency of pethidine administration and vomit in the A group was lower than that in the other groups(P0.05).Conclusion Perioperative celecoxib oral administration can enhance the analgesic effect,reduce the opioids requirements and vomit.Preoperative celecoxib administration is valuable.