Safety and Efficacy Study on Trivalencs Inactivated Vaccines Against Infectious Coryza

Using Page's serovar A,B and C of Avibacterium paragallinarum,trivalent inactived oil-emulsion vaccine against infectious coryza was prepared.Six batches of vaccines used for safety test.2.0 mL/chicken was injected at a time and 0.5mL/chicken at a time for three times.Any side effects were not found.The results showed the vaccines were safeThe vaccine efficacy experment with three batches of vaccines in SPF chicken,30 days after immunization,the chickens were challenged with Page's serovar A,B and C of Avibacterium paragallinarum.The protection rate ≥ 80% in immunized chickens.The commodity chicken were immunized at 42 days old and 110 days old.Nine months after second immunization,the chickens were challenged,the protection rate ≥ 80% in immunized chickens.The SPF chickens were immunized with three batch of vaccines which were stored at 4-8 ℃ for 12 months,30 days after immunization,the chickens were challenged with Page's serovar A,B and C of Avibacterium paragallinarum,The protection rate ≥ 80% in immunized chickens.