Inhibitory Effects of Neuron Delayed Rectifier Potassium Channel under Low Power 2 450 MHz RF Magnetic Field

With the wide applications of electronic devices,people are increasingly exposed on radio frequency(RF) magnetic field.However,the effects of RF magnetic field on people's health remained unclear.Delayed rectifier potassium current(IK) was studied in isolated rat neurons which were exposed to 2450 MHz radio frequency(RF) magnetic field via whole cell patch clamp technique.Ansoft HFSS was used to simulate 6 db gain omni directional antenna magnetic field distribution.The result showed that magnetic field density uniform distribution where 2~3 cm far from the antenna.The 2 450 MHz RF magnetic field was sent out by a 6 dB gain omni directional antenna attached on an Agilent E5070B net analyzer and the transmitting power was 39.81 mw.Compared to the control group,a significant inhibition on the IK after exposure to low power 2 450 MHz RF magnetic field for 5,10 and 15 min,and RF magnetic field markedly affect the activation process of IK,the half-activation voltage changed from(-1.13 ± 2.32)mV to(19.52 ± 1.03)mV(n=10,P 0.05) and the slope factor changed from(23.21 ± 3.29)mV to(13.95 ± 1.27)mV(n=10,P 0.05).The result shows that the 2 450 MHz RF magnetic field can reduce the delayed rectifier potassium currents,and further influenced the physiological functions of neurons.