Synthesis and anti‐HIV Activity of Some New Aminoadamantane Heterocycles.

G. Fytas,George Stamatiou,G. B. Foscolos,Antonios Kolocouris,Nicolas Kolocouris,Myriam Witvrouw,Christophe Pannecouque,E. De Clercq

ChemInform（2010）

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摘要

A new class of aminoadamantane heterocycles has been synthesized and examined for anti-HIV activity. Three compounds proved to be active against the replication of HIV-1 in MT-4 cells with an EC50 ranging from 3.6 to 75.2 μM. No activity was noted with any of the compounds against HIV-2.

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