Study on Detection and Clinical Significance of t-PA,PAI-1 in Acute Cerebrovascular Disease

Objective To explore the change of some factors tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) in the patients with acute cerebrovascular disease and to provide some theorical evidences for the clinical treatment. Methods The level of t-PA,PAI-1 antigen in the 78 patients with acute cerebral hemorrhage, cerebral infarction and transient ischemic attack(TlA) was determined by enzyme-linked immunosorbnent assay(ELlSA) from October 2007 to September 2008.These data were compared with control group,which contains 22 patients. Results To the cerebral hemorrhage,the level of t-PA of experimental group was higher than those of the control group(P0.001).The level of PAI-I antigen was lower than those of the control group(P0.001).The differences between the experimental group and the control group were significant.To the cerebral infarction,the level of t-PA and PAI-1 antigen of experimental group was higher than those of the control group(P0.001).In TIA,the level of PAI-1 antigen in experimental group was higher than those in control group(P0.001).The level of t-PA was lower(P=0.006).The differences between the experimental group and the control group were significant(P0.001). Conclusion To the patients with acute cerebrovascular diseases,there is disturbance of blood coagulation,anticoagulation and fibrolysis.