4′-Thio-RNA: Synthesis, Base Pairing Properties and Interaction with Dimerization Initiation Site of HIV-1

David Dukhan,Florence De Valette,Roland Marquet,Bernard Ehresmann,Chantal Ehresmann,François Morvan,Jean-Louis Barascut,Jean-Louis Imbach

ChemInform（2010）

引用 6|浏览1

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摘要

Abstract in the present paper, we describe the synthesis of a modified 9-mer oligonucleotide, 4′-S-r(UGUGCACCU) containing for the first time 4′-thio-guanosine units. This modified 9-mer was found to inhibit in vitro genomic RNA dimerization as well as the wild type RNA.

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