Chemical constituents in stem bark of Moras cathayana.

Objective To study chemical constituents in the stem bark of Morus cathayana.MethodsThe constituents were separated and purified with chromatographic methods and their structures were elucidated by spectroscopic methods and chemical analyses. All the compounds were tested for their cytotoxicities.Results Eleven compounds,glyasperin F(1),broussoflavonol F(2),lespedezaflavanone C(3),isolicoflavonol(4),sanggenol B(5),sanggenol L(6),sanggenol D(7),sanggenol G(8),sanggenol A(9),dihydroquercetin(10),and quercetin(11),were isolated from the stem bark of M.cathayana. Conclusion Compounds 1-3 are isolated from Morus L.for the first time.Compounds 2,4-6,and 9 exhibit moderate cytotoxic activities against five human cancer cells with the IC50 value of 0.41-7.2 μg/mL.