Effect of torasemide and furosemide on brain edema in patients with acute cerebral hemorrhage
Chinese Journal of Geriatric Heart Brain and Vessel Diseases(2012)
摘要
Objective To compare the therapeutic effect of torasemide and furosemide in combination with 20%mannitol on brain edema in patients with acute cerebral hemorrhage.Methods Eighty-six patients with spontaneous cerebral hemorrhage were randomly divided into observation group(n = 42) and control group(n = 44).The patients underwent dehydration therapy with a same dose of torasemide and furosemide in combination with 20%mannitol for 14 d and head CT on days 1,3,7,and 14 with the volume of intracranial hematoma and cerebral edema calculated. General disturbance coefficient of the two groups was monitored with a non-invasive cerebral edema dynamic monitor at different time points.Level of venous plasma neuropeptide Y was measured in the patients.Incidence of adverse reactions was compared between the two groups.Results The cerebral edema volume,general disturbance coefficient and plasma neuropeptide Y level were significantly lower,and the 24 h urine volume was significantly higher while the amount of 24 h 20%mannitol was significantly lower in observation group than in control group on days 3,7,and 14(3688.6±269.5 ml vs 3072.8±210.4 ml,360.5±21.3 ml vs 440.2±26.3 ml,P0.05).Conclusion The effect of torasemide is better than that of furosemide on cerebral edema in patients with acute intracerebral hemorrhage with a definite therapeutic effect and fewer adverse reactions.
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关键词
Perihematomal Edema
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