Analysis of nuclear morphological parameters on pseudohyperplastic prostaic adenocarcinoma in elderly patients

Objective To analyze nuclear morphological parameters between pseudohyperplastic prostaic adenocarcinoma (PHPA) and benign prostatic hyperplasia (BPH) in elderly patients. Methods Nineteen cases of PHPA and 19 cases of BPH were selected. The areas and perimeters of 10-12 nuclei were measured under high multiple microscope in every case by PAS-9000 pathological image analysis system.The form factors, sphericities and atypical indexes were also counted. Results The areas, perimeters and sphericities of nuclei in PHPA were higher than those in BPH(P0.05), while the form factors and atypical indexes of nuclei in PHAP were lower than those in BPH(P0.05). Conclusions The form of cell nuclear in PHAP was not inerratic. The parameters may be useful in morphological differential diagnosis between PHAP and BPH. It could be used as a new idea for prostatic needle biopsy in the differentiation of prostate diseases in the elderly patients.