2008 Mohnarin report: bacterial drug resistant surveillance of non-ICU inpatients.

OBJECTIVE To investigate the antibacterial drug resistance of clinical isolates from non-ICU inpatients in China.METHODS Clinical isolates were collected by member hospitals of Mohnarin according to the unified protocol.Drug sensitivity test was carried out by using Kirby-Bauer(K-B),MIC or E-test methods according to CLSI 2007.The data were analyzed by WHONET 5.4 software.RESULTS A total of 9273 clinical isolates from inpatients of non-ICU department in Mohnarin member hospitals were collected from Jan to Dec 2008,among which Gram-negative bacteria accounted for 6155(66.4%),and Gram-positive cocci 3118(33.6%).The Escherichia coli (17.1%),Pseudomonas aeroginosa (11.7%),Staphlococci aureus (11.6%),coagulase-negative staphylococci(10.5%) and Klebsiella pneumoniae were the most common isolates.Meticilli-resistant strains in Staphlococci aureus(MRSA) and coagulase-negative staphylococci (MRCNS) accounted for 59.7% and 85.2%,respectively.There was no glycopeptide-resistant staphylococcus to be found,but a small part of coagulase-negative staphylococcus were teicoplanin-intermediate or drug-resistant strains.4.2% and 0.9% of respective Enterococcus faecalis and E.faecium isolates were resistant to vancomycin,3.0% and 0.5% resistant to teicoplanin.The detected rates of ESBLs-producing E.coli and K.pneumoniae were 31.4% and 17.4%,respectively,Enterobacteriaceae isolates were still highly sensitive to imipenem and meropenem,the average resistant rate was less than 6%,and more than 60.0% of E.coli isolates resistant to quinolones.The drug resistant rates of Stenotrophomonas maltophilia to quinolones and minocycline were below 20.0%.CONCLUSION Enterobacteriaceae and Staphylococcus are the predominant pathogens in non-ICU inpatients.Bacterial drug resistance is severe and shows an upward tendency.The surveillance result is very important for the rational application of antimicrobial agents.