Outcomes of dezocine in inhibiting the stress response to tracheal intubation during induction of general anaesthesia

Objective To observe the outcomes of dezocine in inhibiting the stress response to tracheal intubation during induction of general anaesthesia.Methods Eighty patients undergoing general anaesthesia were divided into two groups with 40 cases each.Anesthesia was induced with midazolam 0.05-0.1mg/kg,propofol 1-2mg/kg and cisatricurium 0.15-0.25mg/kg plus dezocine 0.2mg/kg(group D) or fentanyl 3μg/kg(group F).The mean artery pressure(MAP) and heart rate(HR) were recorded 5min before(T0) and immeadiately before intubation(T1),at 1min(T2),5min(T3) and 10minu(T4) after intubation.Plasma concentrations of epinephrine(E) and norepinephrine(NE) were tested at T0,T2 and T4.Results MAP and HR at T1-T4 were not significantly different from those at T0 in group D(P0.05).The HR in group F was lower at T1 and T4 than that at T0 and that in group D(P0.05),but was higher at T2 and T3 than that at T0 and that in group D(P0.05).Compared to before,the concentrations of E and NE increased after intubation in both groups.Plasma concentrations of E and NE in group F were significantly higher at T2 than those at T0(P0.05),which were not in group D(P0.05).Conclusion Dezocine is better than fentanyl in inhibiting the stress response to tracheal intubation during induction of general anaesthesia.