Control Study of Correlation of Objective Index in Chronic Heart Failure with Traditional Chinese Medicine Syndrome Types

Objective:To investigate the possibility of BNP,CRP,LVEF as biological markers for traditional Chinese medicine(TCM) syndrome types and to analyze relation between BNP,CRP,LVEF levels and TCM syndrome types in patients with chronic heart failure(CHF).Methods:217 patients with CHF were selected as research objects and then 23healthy persons were as control objects.The clinical data of 217 patients with CHF was analyzed with TCM syndrome differentiation,and BNP and CRP levels were analyzed quantitatively with Immunofluorescence assay.All the patients were examined with cardiac color dopplar ultrasound and the result of LVEF determination was analyzed.Results:The BNP concentrations in patients with CHF were significantly higher than that in healthy controls.BNP concentrations were increased with CHF severity and were positively correlated with the NYHA classification system(r=0.672,P=0.0000.05).The LVEF concentrations in patients with CHF were significantly lower than that in healthy controls.LVEF concentrations were reduced with CHF severity and were negatively correlated with the NYHA classification system(r =-0.527,P=0.0000.05).The BNP concentrations were positively correlated with TCM syndrome types(r=0.819,P= 0.0000.05).The NYHA classification system was positively correlated with TCM syndrome types(r=0.407,P0.05).The LVEF concentrations were negatively correlated with TCM syndrome types(r =-0.69,P=0.0000.05).The CRP in CHF group and control group had significant difference(P0.05).The CRP concentrations were positively correlated with TCM syndrome types(r=0.713,P=0.0000.05).With CHF intensified and CRP gradually increased,CRP and NYHA cardiac function correlation classification and the grading test between heart CRP had significantly different values(P0.05).Conclusion:There was a relationship between BNP,CRP and LVEF levels and TCM syndrome types in patients with CHF.BNP,CRP and LVEF levels might be biological markers for TCM syndrome type determination in patients with CHF.