Analysis on factors associated with adverse reactions after transfusion of apheresis platelets

Objective To investigate the factors associated with the adverse reactions after transfusion of apheresis platelets and provide a basis for the development of preventive measures.Methods Thirteen cases of adverse reaction after transfusion of apheresis platelets were collected from May to June,2013 in a hospital in Dongguan City,Guangdong Province,China,serving 16 cases without adverse reaction after transfusion as control.The investigation protocol was designed based on the basic information of recipients and donors,and the data were collected for statistical analysis.The basic information of recipients included sex,age,blood transfusion history,medication history and changes of peripheral blood cells [differences between absolute values of leukocytes,eosinophils,basophils,monocytes before and after transfusion as well as platelet recovery(PR) and globulin content in plasma after transfusion],while that of donors included sex,age,times of donating,time for storage of platelets before transfusion,the type and circulation capacity of platelet collector,leukocyte counts before donating and presence or absence of adverse reaction during donating.Results The age,sex,blood transfusion history,medication history,PR as well as the differences between absolute values of leukocytes,eosinophils,basophils,monocytes before and after transfusion,globulin content in plasma after transfusion of recipients in test group showed no significant difference with those in control group(P 0.05).However,the time for storage of platelets before transfusion,the sex,age,times of donating of donors,the type and circulation capacity of platelet collector and leukocyte counts before donating in test groups showed no significant difference with those in control group.Conclusion The adverse reactions after transfusion of apheresis platelets showed no relationship to the basic information of recipients and donors as well as peripheral blood cell count and plasma globulin of recipients.It indicated that the allogeneic plasma protein was the major cause for the adverse reaction after transfusion of apheresis platelets. Washing platelets was recommended to the recipients with history of adverse reaction after transfusion.