Analysis of the relationship between thyroid antibodies and thyroid disfunction diseases in checkup people

Objective To analyze the relationship between thyroid antibodies and thyroid disfunction diseases in checkup people. Methods A total of 15 007 cases of checkup adults were recruited between January 1 2009 to December 31 2013 from Health Checkup Department, Peking Union Medical College Hospital Chinese Academy of Medical Sciences. There were 7826 cases of male, 7181 cases of female, mean age of(44.38±11.62) years old. Serum TPOAb,TGAb, TSH, free T3, free T4 were detected. Results The total positive rate of TPOAb was 8.97%, its positive rate in females was significantly higher than that in males(13.97% vs 4.38%,P 0.01), its peak rate in 60-70 age group,which was 17.09%. The total positive rate of TGAb was 9.58%, its positive rate in females was significantly higher than that in males(16.17% vs 3.54%,P 0.01), its peak rate in 50-60 age group, which was 18.39%. In the clinical hyperthyroid, subclinical hyperthyroid, clinical hypothyroid and subclinical hypothyroid four subgroups, the positive rate of TPOAb and TGAb both were 38.81%, 12.32%, 57.50% and 19.17%, significantly higher than those in non-thyroid dysfunction disease group, which was 3.44%( all P 0.01,OR=39.35, 4.37, 65.75 and 7.61 respectively). Other than single antibody positive group, OR was doubled. Conclusion Immune mechanism plays an important role in the thyroid dysfunction diseases. The chronic and potential damage occur when the thyroid antibody appeared. So it is essential to follow-up these people, especially in both antibodies positive, in order to facilitate prevention, early diagnosis and treatment of thyroid dysfunction diseases.