Clinical value analysis of combined NT-proBNP and cTnI in myocardial injury after acute carbon monoxide poisoning

Objective:To investigate the clinical value of combined NT-proBNP and cTnI in myocardial injury after acute carbon monoxide poisoning(ACOP).Method:A total of 68 ACOP patients hospitalized from 2012.10 to 2014.02 were divided into three groups according to CO poisoning degree which were mild,moderate and severe ACOP.30 healthy volunteers during the same period were the control group.To test serum NT-proBNP and cTnI immediately after admitted to hospital and to compare differences between ACOP groups with the control group and differences among mild,moderate and severe ACOP groups.Result:Compared with the control group,NT-proBNP and cTnI increased significantly in mild,moderate and severe group with ACOP(P0.01).Compared with the mild ACOP group,NT-proBNP and cTnI increased significantly in moderate and severe group with ACOP(P0.01).Compared with the moderate group,NT-proBNP and cTnI increased significantly in severe group with ACOP(P0.01).NT-proBNP is positively correlated with cTnI(r=0.957,P=0.043).Conclusion:The levels of NT-proBNP and cTnI increased significantly after ACOP,combined detection of NT-proBNP and cTnI can improve the sensitivity and specificity of myocardial injury and have very high diagnosis value in assessment of myocardial injury after ACOP.