Abstract 3623: Association between helicobacter pylori infection and lung cancer: a meta-analysis.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Lung cancer is still the leading death cause of cancers. Helicobacter pylori (Hp) is one of the most common bacteria infecting human. In the past decade, some investigators endeavored to clarify the possible association of lung carcinoma risk with Hp infection, with conflicting results. Whether Hp infection is a risk factor for lung cancer remains largely uncertain. We performed a meta-analysis on the association between Hp infection and lung cancer. Medline, OVID, EMBASE and Chinese Biomedical Literature database (CBM) database were comprehensively searched for the relevant literatures until September 2012. Meta-analysis was performed using the program Review Manager 6.2. Heterogeneity was also explored. Seven case-control studies with a total of 1011 cases and 1040 controls met the inclusion criteria and were included in the meta-analysis. Hp infection was detected seropositivity for antibodies against Hp using ELISA in all 7 studies. Our meta-analysis showed that patients with lung cancer have a significantly higher rate of seropositivity for antibodies against Hp than controls, with an odds ratio of 3.15 (95% CI, 1.49-6.67). This meta-analysis suggests there may be a potential effect of Hp infection on the risk of lung cancer. This warrants further large and well-designed studies for thorough investigation. Citation Format: Na Wu, Bin Xu, Yafei Li. Association between helicobacter pylori infection and lung cancer: a meta-analysis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3623. doi:10.1158/1538-7445.AM2013-3623