Metabolismo mineral en niños en diálisis peritoneal crónica

Introduction:  Children with chronic kidney disease (CKD) and receiving peritoneal dialysis (PD) have disorders of mineral metabolism that impact their growth, survival and cardiovascular functions. New molecular markers offer a better understanding of the pathophysiology of this disease.  Objective:  To characterize some components of mineral metabolism, with emphasis on FGF23/Klotho and cardiovascular functions (CV) of these patients.  Patients and Method:  Prospective observational cohort study. Exclusion criteria: serum 25 (OH) vitamin D 38 g/m 2  was confirmed in 20/28 patients.  Conclusions:  The values of FGF23, and PTH are elevated in children with CKD on PD. Klotho levels in CKD patients are lower than control children. A strong association of calcemia with FGF23 and PTH is reported. Residual renal function is inversely associated with FGF23 and Klotho. A high incidence of left ventricular hypertrophy was found evidencing a cardiovascular compromise in these patients.