Copper(II)‐Catalyzed Enantioselective Hydrosilylation of Halo‐Substituted Alkyl Aryl and Heteroaryl Ketones: Asymmetric Synthesis of (R)‐Fluoxetine and (S)‐Duloxetine.
ChemInform(2014)
摘要
A series of chiral alcohols, e.g. compounds (II) and (IV), is prepared by enantioselective hydrosilylation of corresponding ketone precursors using cupric acetate and a P-Phos ligand as catalytic system.
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关键词
enantioselective hydrosilylation,asymmetric synthesis,heteroaryl ketones,halo-substituted
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