Meta-analysis on Risk Factors of Sleep Disorder after Stroke

Objective To investigate the common risk factors of sleep disorder after stroke through a metaanalysis. Methods A total of 11 papers were included. A comprehensive quantitative analysis was conducted by meta-analysis method. Test for heterogeneity was performed by using Review Manager 5.1 software. The pooled odds ratio (OR) value and 95% confidence interval (CI) were also calculated. Results There were five risk factors having statistical significance with sleep disorder after stroke. They were the habitual snoring (OR 14.77, 95%CI 5.52~39.53), hypertension (OR 1.3, 95%CI 1.03~1.66), diabetes (OR 1.41, 95%CI 1.08~1.84), drinking (OR 1.59, 95%CI 1.19~2.12), cortical-type stroke (OR 1.31, 95%CI 1.06~1.63), respectively, and the combined result was stable. But the relationship between gender (OR 1.12, 95%CI 0.96~1.31), hyperlipidemia (OR 0.96, 95%CI 0.7~1.33), smoking (OR 1.27, 95%CI 0.73~2.20), stroke history (OR 1.05, 95%CI 0.74~1.49) and sleep disorder after stroke was not determined. Conclusion The limited available evidence suggests that hypertension, diabetes, drinking, habitual snoring and cortical-type stroke are the risk factors of sleep disorder after stroke.