Characteristics analysis of corneal endothe lial cells in patients with age-related cata ract

Objective To analyze the corneal endothelial cells in patients with age-related cataract and discuss the possibility of quantitative analysis of eye aging.Methods One hundred and ninty-nine patients with age-related cataract (211 eyes) who received operation treatment in our hospital from August to December in 2011,based on the lens nucleus hardness,were divided into Ⅱ,Ⅲ and Ⅳ nuclear-grade groups,and further divided into three subgroups as65 years old,65-80 years old and80 years old according to age.The thickness of central corneal,the density of CEC cells,the percentage of hexagonal cells and the coefficient of variation of all groups were measured by the corneal endothelial microscope.Results The CCT and CD between the levels of lens nucleus,and between the subgroups were not statistically significant(all P0.05).The Ⅲ class nuclear group65 years old subgroup HEX (69.18±19.16)% was higher,compared with the 65-80 years old groups (54.18 ±17.33)%,the difference was statistically significant(P0.05).The HEX difference in Ⅱ and Ⅲ class nuclear groups had no statistical significance(P0.05).Compared with Ⅱ and Ⅲ class nuclear group,the CV in Ⅳ class nuclear group was bigger with (23.55±2.61)% difference,and was smaller than80 years old sub group (25.76±2.47)%,CV in the Ⅲ class nuclear group65 subgroup was (23.09±2.91)%,compared with other sub-group,this group was smaller,and the differences were statistically significant (all P0.05);The difference of CV in sub-groups of Ⅳ class nuclear group had no statistical significance(P0.05).Conclusion CEC and CD is basically the same in different lens nuclear level and different age of patients with age-related cataract,but there are morphological differences.The inspection of CEC morphology can quantitatively reflect the degree of eye aging in patients with age-related cataract.