Expression and significance of phosphoinositide 3-kinase and vascular endothelial growth factor proteins in esophageal squamous cell carcinoma

Objective To study the expression of phosphoinositide 3-kinase(PI3K)and vascular endothelial growth factor(VEGF)in esophageal squamous cell carcinoma(ESCC)and to investigate the relationship among the expression of PI3K and VEGF,carcinogenesis and progression of esophageal carcinoma.Methods PI3K and VEGF expression were detected in 24cases of normal esophageal mucosa,94 cases of primary tumor tissues with streptavidin peroxidase conjugated method(SP)immunohistochemical method.Results There were significant differences of PI3K and VEGF expressions between esophageal carcinoma and normal mucosa epithelium,71.3%(67/94)vs 4.2%(1/24),61.7%(58/94)vs 0(both P0.01).Significant difference existed in the expression of PI3K,VEGF and the metastasis of lymph node 92.0%(46/50)vs 47.7%(21/44),76.0%(38/50)vs 45.4%(20/44)(both P 0.01).The positive expression rate of VEGF had the relationship with pathological differentiation invasive depth(P 0.01).Correlation existed between PI3Kand VEGF expression(C=0.311,P0.01).Conclusion The over expressed PI3K and VEGF play important roles in carcinogenesis and progression of esophageal carcinoma and can be used as valuable biomarkers to evaluate biological characteristics in esophageal carcinoma.