Endobronchial Volume Reduction with Lung Sealant (Aeriseal®); PostInterventional Fever and Malaise Treated with Combined Therapy ofBroad- Spectrum Antibiotic and Supportive Prednisolone

Both our patients with advanced emphysema and hyperinflation underwent endoscopic volume reduction with endoscopic tissue sealant (AeriSeal®), collateral flow was confirmed by using the Chartis system®. Both patients experienced transient fever with elevated leukocyte counts and increased serum acute phase protein, malaise, chest discomfort and shortness of breath after the procedure. We gave both patients broad- spectrum antibiotics with supportive prednisolone 30 mg for around 7 days. They both benefited from this combined therapy and were able to recover fast. The follow- up evaluations of those two patients showed improved lung function (increased FEV 1, improved 6- minute walk test and a reduction of RV) with improved quality of life of both patients.