РОЛЬ КОРРЕКЦИИ НЕДОСТАТОЧНОСТИ 25(OH)D У ПАЦИЕНТОК С СИНДРОМОМ ПОЛИКИСТОЗНЫХ ЯИЧНИКОВ

Objective. To estimate the correction failure 25 (OH) D in patients with polycystic ovary syndrome. Material and Methods. The study involved 44 patients with polycystic ovary syndrome, aged 31.32 ± 5.05, who were randomly assigned to 2 groups: 1st – obtained coca biguanides and Kolekaltsiferol, second – combined oral contraceptive (combined hormonal ) and biguanides. The comparison group consisted of 22 healthy women matched for age and sex. Polycystic Ovarian Syndrome (PCOS) was verified on the Оригинальные статьи Бюллетень сибирской медицины, 2015, том 14, № 5, с. 47–53 53 basis of diagnostic criteria ESHRE / ASRM (2012). 25 (OH) vitamin D was determined by enzyme-linked immunosorbent assay (ELISA ng/ml). Examined glucose and fasting insulin, HOMA index of insulin re-sistance. Depression was assessed using the Beck test. Statistical analysis – R-system. Results. The patients with PCOS defined by the expression deficit of 25 (OH) D, which is associated with hyperandrogenism, hyperglycemia, hyperinsulinemia, insulin resistance, as well as depression. Ad-mission kolekaltsiferola leads to improved glucose metabolism and manifestations of PCOS, and also significantly reduces the parameters of OT, OT / OB, depression. Conclusion. Failure correction of 25 (OH) D contributes to the improvement of metabolic and psycho-logical parameters of fertility.