Design and Synthesis of Azobenzene Template Based Sulfonamide for Capture of HCAII: Dependence of Efficiency on E—Z Geometry.

Partha Sarathi Addy,Baisakhee Saha,Arpita Panja,Amit Das,Amit Basak

ChemInform（2014）

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摘要

Abstract We report the synthesis of azobenzene template based sulfonamides 1 and 2 for capture of Human Carbonic Anhydrase II (HCAII). Out of these, 1 showed successful capturing of the protein, only when it is photo-isomerized to the Z form thus demonstrating the importance of spatial proximity of the reactive and selective functionalities.

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azobenzene template based sulfonamide,hcaii,cheminform abstract

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