Meta Analysis on the Expression and Clinical Significance of COX-2 in Oral Squamous Cell Carcinoma

Objective: To investigate the expression and significance of COX-2 in the organization of oral squamous cell carcinoma(OSCC).Methods: The Cochrane Library,Embase,PubMed,CNKI,VIP,WanFang and CBM databases were searched for such as COX-2 and OSCC-related Case-control study.Revman5.0.1 software was adopted to test for heterogeneity of the selected research literature and analyze the correlation of COX-2 and OSCC by calculating OR and 95% CI.Results: A total of 19 case-control studies were included in the study,the case group(OSCC group) was 945 cases and in the control group(NOM) was 243,the Meta analysis of results showed that the expression difference of COX-2 in OSCC and normal oral mucosa(NOM) tissue was statistically significant(OR=24.19,95%CI=12.42~47.11,P0.00001).Conclusion: The high expression of COX-2 may play an important role in the occurrence and development of OSCC,which has an important significance for the early diagnosis and and treatment of OSCC,but the evidence is not yet as an independent factor to determine the prognosis of oral squamous cell carcinoma.