What are the first-line treatments for rheumatoid arthritis ?

The management of rheumatoid arthritis has not stopped evolving after the advent of new effective therapies and the emergence of new concepts such as tight control, early and aggressive treatment with a target of remission, or at least low disease activity. Strategies to follow are now well codified by the new recommendations of the European League Against Rheumatism (EULAR) 2013, which clearly emphasized that conventional disease-modifying antirheumatic drugs (DMARDs) with methotrexate as a leader are the first-line therapies to use in the treatment of rheumatoid arthritis.