Fomentation on Expression of TNF-α in Ear Vein Tissue of Chemotherapy Phlebitis Rabbits Model

Objective:To study the expression of TNF— a in ear vein tissue of chemotherapy phlebitis rabbits model by fomentation.Methods:40 New Zealand white rabbits were randomly divided into 5 groups,respectively,the control group,the injection four types of chemotherapy drugs groups.Using the marginal ear vein injection drug law,the rabbit chemotherapy phlebitis model was made.Each rabbit ear vein injection of chemotherapy drugs were treated with fomentation,and the other side by the same chemotherapy drugs ear vein injection without any treatment.Then the rabbit model was killed after 4 days,to take marginal ear vein and local organizations,using the immunohistochemical method for measuring expression of TNF— a in the tissue.The expression intensity was analyzed by IPP6.0 software.Results:There was no difference between the control group and other 4 groups of experiment rabbit ears(P0.05);there was difference between the control group and other 4 groups of check rabbits ears(P0.05);their comparative experimental group rabbit ears found that the expression of TNF— a in fomentation tissue was weaker than that in the another side,and there was difference between two groups(P0.05).Conclusion:Fomentation could prevent rabbits from chemotherapy phlebitis.