An oral cocktail study on potential drug interactions of a proprietary nutraceutical combination containing berberine and monacolin in healthy volunteers

Figure 1. Mean plasma concentrations for each probe administered as kt il l The patented proprietary combination of natural nutraceuticals (AP) is well described for its lipid-lowering properties. The major components of AP are berberine hydrochloride and fermented red yeast rice extract (Monascus purpureus) which contains monacolin Berberine is metabolised predominantly by CYP2D6, but also b CYP3A4 d CYP1A2 d f d t b i hibit f Introduction