Dynamic Resistance Training Promotes Better Neuromuscular Benefits And Reduces Oxidative Stress In Healthy Wistar Rats: 1828 Board #89 May 31 3 30 PM - 5 00 PM

PURPOSE: Resistance training (RT) is used as a non-pharmacological tool in the prevention and treatment of various diseases. However, few studies have evaluated the different neuromuscular adaptations promoted by dynamic (DRT) and isometric (IRT), and their impact on redox status.This study aimed to compare the different adaptations on muscle strength and oxidative stress in healthy Wistar male rats. METHODS: Fifteen male Wistar rats at 12 weeks of age were randomized into 3 groups: control group (CTL; n = 5), DRT (n = 5) and IRT (n = 5). All animals were adapted for 2 weeks on the vertical ladder. After the animals were submitted to dynamic strength muscle (DSM) (test performed every 15 days) and maximum isometric resistance (MIR) (pre and post-training) tests. Both DRT and IRT were performed 5 times a week on non-consecutive days for 12 weeks, with a duration of ~ 22 min per session, consisting of 1 set of 8 uninterrupted climbs for 1 min, with a 30% overload of DSM. The animals of the IRT group remained in isometry for 1 minute. The level of significance was set at P<0.05. RESULTS: The DRT group presented a greater gain of the DSM (390±86 and 686±66 g, pre and post-training, P<0.05) compared to the groups CTL (339±65 and 427±39 g, pre and post-training, P<0.05) and IRT (369±31 and 393±41 g, pre and post-training, P<0.05). The DRT (6.9±3.4 and 24.7±5.3 min, pre and post-training) and IRT (9.6±4.6 and 39.1±15.9 min, pre and post-training) groups showed the same gain in MIR (P>0.05). The DRT group presented reduction of lipid peroxidation (17±4 and 9±3 μM, pre and post-training, P<0.05) (TBARS), with increased bioavailability of nitric oxide (NO) (122±28 and 177±14 μM, pre and post-training, P<0.05) and total antioxidant capacity (627±32 and 715±45 μM, pre and post-training, P<0.05) (TAC). These redox status indicators did not change between CTL; TBARS (15±5 and 17±7 μM, pre and post- training), NO (118±15 and 125±32 μM, pre and post-training) and TAC (636±29 and 660±10 μM, pre and post-training) and IRT; TBARS (16±3 and 15±3 μM, pre and post- training), NO (126±18 and 133±14 μM, pre and post-training) and TAC (631±8 and 647±20 μM, pre and post-training) groups (P>0.05). CONCLUSIONS: These results suggest that DRT promotes better neuromuscular benefits with improved oxidative stress in healthy Wistar male rats.