123 I-Metaiodobenzylguanidine SPECT and Myocardial Perfusion Mismatch in Pediatric Patients with Congenital Heart Disease: Comparison with Simultaneous 99m Tc-Sestamibi SPECT Image and Phase Analysis

The issue of "Shinzo Kaku Igaku" (Japanese Journal of Nuclear Cardiology) contains her original award-winning article.She and her colleagues aimed to assess the differences between 123 Imetaiodobenzylguanidine (MIBG)-SPECT scan accumulation patterns and 99m Tc-sestamibi (MIBI)-SPECT scan images with phase analysis observed in pediatric patients with congenital heart disease (CHD).Her resultsshowed that decreased cardiac MIBG uptake reflected sympathetic denervation secondary to CHD operative procedures in patients with CHD who exhibited a mismatch in uptake between the MIBG and MIBI.In cases with normal perfusion and abnormal MIBG, it was shown that her group should consider the possibility of underlying CHD and its associated procedures in adult CHD patients.