MEMS aptasensor for label-free detection of cancer cells

Combining a single step biofunctionalization method with a low cost polymeric MEMS platform, an efficient label free aptasensor is developed for direct detection of cancer cells. Utilizing the high binding affinity and specificity of the aptamer AS1411 for the cancer cell marker protein Nucleolin, we could detect as low as 800 cancer cells. Till date there is no report on a label free cancer cell biosensor with an integrated piezoresistive transduction.