Lower VO2max In Individuals With A Family History Of Diabetes is normalized After 8-weeks Exercise: 3201 Board #70 June 2 8 00 AM - 9 30 AM

A family history of type 2 diabetes (FH+) is considered a risk factor for insulin resistance and poor cardiorespiratory fitness. However, it is not known if exercise induced improvement in maximal aerobic capacity (VO2max) is impeded by a FH+. PURPOSE:The purpose of this study was to determine if normoglycemic, sedentary, Hispanic men with FH+ have a lower VO2max compared to those without a family history of type 2 diabetes (FH-) and if the improvement in VO2max after 8-weeks of combined exercise training is comparable between FH- and FH+. METHODS: 19 participants (mean ± SEM: age:23±0.56 years; BMI: 26.9±0.98 kg/m2) underwent 8 weeks of combined exercise training (35 min aerobic at 60-75% VO2max followed by 6 full-body resistance exercises (3x/week)). VO2max was measured using ParvoMedics 2400 metabolic measurement system during a standardized graded exercise test performed on a treadmill. Body composition was assessed by DXA. RESULTS: VO2max was significantly lower in FH+ compared to FH- at baseline (3.57 ± 1.7 vs. 4.08 ± 0.15 L/min; p=0.04). After 8 weeks of combined exercise training FH+ significantly improved VO2max (3.57 ± 0.17 to 3.82 ± 0.16 L/min; p=0.002), whereas no improvement was observed in FH- (4.08 ± 0.15 to 4.21 ± 0.17 L/min; p=0.16). There was no difference in VO2max between groups after 8 weeks of exercise training (p=0.67). Lean body mass significantly improved in both groups (FH- 56.6 ± 2.1 to 58.5 ± 2.1 kg; p=0.01; FH+ 51.8 ± 1.95 to 53.4 ± 1.79 kg; p=0.01) and fat mass remained unchanged (p=0.38). CONCLUSIONS: A family history of diabetes may negatively impact cardiorespiratory fitness in a normoglycemic, sedentary, Mexican American population. A combined exercise training program (8 weeks) is effective in normalizing this defect.