The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics
Family Practice and Palliative Care(2016)
Abstract
Sizofreni hastalarinda antipsikotiklerin depresyon duzeyine etkisi: klozapine karsi diger atipik antipsikotikler 1 Ruh Sagligi ve Hastaliklari Ana Bilim Dali, Tip Fakultesi, Canakkale Onsekiz Mart Universitesi, Canakkale, Turkiye 2 Beyhekim Psikiyatri Klinigi, Konya Egitim ve Arastirma Hastanesi, Konya, Turkiye 3 Gulabibey Aile Sagligi Merkezi, Corum, Turkiye OZET Giris: Depresif belirtiler sizofreninin hemen tum evrelerinde gorulmektedir. Sizofreni tedavisinde kullanilan antipsikotik ilaclar arasinda tedaviye direncli sizofrenide en etkili antipsikotik olan klozapin’in bu hasta grubunda intihar riskini azalttigi bilinmektedir. Bu calismanin amaci klozapin kullanan sizofreni hastalarinda depresyon duzeyini saptamak, diger atipik antipsikotik ilaclari kullanan hastalarla karsilastirmaktir. Yontem: Bu calisma Aralik 2012-Mayis 2013 tarihleri arasinda DSM-IV-TR’ye gore sizofreni tanili hastalarin degerlendirildigi kesitsel-tanimlayici bir calismadir. Tum katilimcilarin demografik ozellikleri ve Kisa Psikiyatrik Degerlendirme Olcegi (KPDO), Pozitif ve Negatif Sendrom Olcegi (PNSO) ve Calgary Sizofrenide Depresyon Olcegi (CSDO) puanlari degerlendirildi. Bulgular: Hastalarin %23,6’si (n = 13) klozapin, %76,4’u (n = 42) diger antipsikotikleri kullandigi tespit edildi. Klozapin kullanan hastalarin %23,1’i (n = 3) kadin, %76,9‘u (n=10) erkekti. Klozapin kullanan hastalarin yas ortalamasi 43,0 ± 11,2 idi. Klozapin kullanan hastalarin depresyon duzeyi %15,4(n = 2) olarak bulundu. Klozapin kullanan ve kullanmayan hastalarin yas, cinsiyet, medeni durum, egitim sureleri, hastalik baslangic yasi, depresyon varligi, intihar girisimi oykusu degerlendirildiginde her iki grup arasinda istatistiksel olarak anlamli fark saptanmadi. Sonuc: Sizofreni hastalarinda klozapin kullaniminin depresyon duzeylerini etkilemedigi ve diger antipsikotikler ile kiyaslandiginda depresyon uzerinde farkli bir etkileri olmadigi tespit edilmistir. Anahtar kelimeler: atipik antipsikotikler, depresyon, klozapin, sizofreni ABSTRACT Introduction: Depressive symptoms may occur in all stages of schizophrenia disorder. Clozapine is the only antipsychotic that has been demonstrated superior efficacy in schizophrenia and suicidal ideation. The aim of this study is to evaluate depressive symptoms in patients with schizophrenia treated with clozapine and to compare with treated with other atypical antipsychotics. Methods: A cross-sectional descriptive study was carried out on patients with schizophrenia according to DSM-IV-TR between December 2012 and May 2013. All participants were evaluated for demographic characteristics and points of Brief Psychiatric Rating Scale, Positive, Negative Syndrome Scale, and Calgary Depression Scale for Schizophrenia. Results: A total 23.6% (n = 13) patients treated with clozapine, while 76.4% (n = 42) patients were treated with other antipsychotic drugs. 23.1% (n = 3) of patients taking clozapine were women, 76.9% (n = 10) were male. The mean age of patients treated with clozapine was 43.0 ± 11.2. The level of depression of patients treated with clozapine was 15.4% (n = 2). No statistically significant difference was found between patients between treated with clozapine and other antipsychotics regarding age, sex, marital status, education years, work history, age at onset of disease, depression and history of suicide attempt Conclusion: As a result of this study it is found that clozapine did not effect on the level of depression in patients with schizophrenia, and depression level of patients with schizophrenia treated with clozapine had no difference from patients treated with other antipsychotics. Keywords : atypical antipsychotics, clozapine, depression, schizophrenia Basvuru / Submission: Mart / March 11, 2016 Kabul / Acceptance: Haziran / June 2, 2016 Yazisma / Correspondence: Dr. Hulya Ertekin, Ruh Sagligi ve Hastaliklari Ana Bilim Dali, Tip Fakultesi, Canakkale Onsekiz Mart Universitesi, Canakkale, Turkiye E-mail: md.ertekin@gmail.com Atif / Cite: Ertekin H, Ozayhan HY, Er M, Yakar B. Sizofreni hastalarinda antipsikotiklerin depresyon duzeyine etkisi: klozapine karsi diger atipik antipsikotikler. Fam Pract Palliat Care. 2016;1(2):31-34 G M T Dili algila Afrika Dili Almanca Arapca Arnavutca Azerice Baskca Belarusca Bengalce Bosnakca Bulgarca Burmaca Cebuano Chicheva Cekce Cince Basit Cince Eski Danca Endonezyaca Ermenice Esperantoca Estonyaca Farsca Felemenkce Filipince Fince Fransizca Galce Galicyaca Gucerat Dili Gurcuce Haiti Creole Hausa Dili Hirvatca Hintce Hmong Dili Ibranice Igbo Dili Ingilizce Irlandaca Ispanyolca Isvecce Italyanca Izlandaca Japonca Javanese Kambocyaca Kannada Katalanca Kazakca Korece Laoca Latince Lehce Letonca Litvanyaca Macarca Madagaskar Dili Makedonca Malayalam Malezya Dili Malta Dili Maori Dili Marathi Mogolca Nepalce Norvecce Ozbekce Pencap Dili Portekizce Rumence Rusca Sesotho Dili Seylanca Sirpca Slovakca Slovence Somalice Sundanizce Svahili Tacikce Tamil Tay Dili Telugu Turkce Ukraynaca Urduca Vietnamca Yidce Yoruba Yunanca Zulu Afrika Dili Almanca Arapca Arnavutca Azerice Baskca Belarusca Bengalce Bosnakca Bulgarca Burmaca Cebuano Chicheva Cekce Cince Basit Cince Eski Danca Endonezyaca Ermenice Esperantoca Estonyaca Farsca Felemenkce Filipince Fince Fransizca Galce Galicyaca Gucerat Dili Gurcuce Haiti Creole Hausa Dili Hirvatca Hintce Hmong Dili Ibranice Igbo Dili Ingilizce Irlandaca Ispanyolca Isvecce Italyanca Izlandaca Japonca Javanese Kambocyaca Kannada Katalanca Kazakca Korece Laoca Latince Lehce Letonca Litvanyaca Macarca Madagaskar Dili Makedonca Malayalam Malezya Dili Malta Dili Maori Dili Marathi Mogolca Nepalce Norvecce Ozbekce Pencap Dili Portekizce Rumence Rusca Sesotho Dili Seylanca Sirpca Slovakca Slovence Somalice Sundanizce Svahili Tacikce Tamil Tay Dili Telugu Turkce Ukraynaca Urduca Vietnamca Yidce Yoruba Yunanca Zulu Konusma fonksiyonu 100 karakter ile sinirlidir Secenekler : Gecmis : Yardim : Geribildirim Kapat
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Key words
atypical antipsychotics,clozapine,depression,schizophrenia,atipik antipsikotikler,depresyon,klozapin,şizofreni
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