163. Mood-Associated Gsk3β/Fxr1P Pathway Regulates Homeostatic Plasticity
Biological Psychiatry(2017)
Abstract
Fragile X mental retardation syndrome-related protein 1(Fxr1P) is a RNA binding protein identified as a potential risk factor for several mental illnesses. Recently we demonstrated that Fxr1P can be directly phosphorylated by Gsk3β and regulated in response to treatment with mood stabilizer drugs. Furthermore, interaction between human functional polymorphisms in the GSK3B and FXR1 genes contributes to mood regulation. However, the mechanism behind mood regulation by Gsk3/Fxr1P pathway remains unclear.
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Key words
pathway,mood-associated
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