Modelo de interaccion entre quercetina (3,5,7,3p,4p-pentahidroxiflavona) y factor de choque térmico (HFS) humano
Revista Cuarzo(2017)
Abstract
INTRODUCTION. The expression of the HSP stress inducted are regulated by the Shock Thermic Factor (HSF), that exists in an inactive form as a monomer and when it becomes a trimer can make a bind to DNA activating the HSP transcription. OBJECTIVE. Design a computational model that helps elucidate possible interactions between quercetin fl avonoid and proteins such as HSF-1. METHODOLOGY. To observe how the quercetin possibly affects the timerization of HFS, we make an homology model of the human shock factor (HFS-1), obtaining a high structural homology model with the same protein in Kluyveromyces lactis, this model was used to make docking with the fl avonoid quercetin ( 3,5,7,3p,4p-pentahidroxifl avone). RESULTS AND CONCLUSION. The doking result shows that the quercetin docks to a loop (wing), that is important in the protein-protein interaction, possibly affecting they’re trimerization.
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Key words
human shock thermic factor,quercetin,p-pentahidroxiflavone
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