FeF3-Catalyzed MCR in PEG-400: Ultrasound Assisted Synthesis of N-Substituted 2-Aminopyridines.
ChemInform(2016)
摘要
FeF3 catalyzed four component reaction under ultrasound irradiation was explored for the first time to prepare N-substituted 2-aminopyridines in good yields. The methodology involved the use of readily available starting materials and PEG-400 under mild reaction conditions in the presence of air. The one-pot methodology afforded a range of compounds of pharmacological interest indicating its potential in generating a diversity based library of small molecules useful for medicinal chemistry and drug discovery.
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关键词
ultrasound assisted synthesis,mcr,n-substituted
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